CESAR Trial

The first international presentation of the results in the public domain were by Giles Peek at the Society of Critical Care Medicine's 37th Critical Care Congess in Hawaii, February 2008.

The Final Collaborators meeting was held on Wednesday 5th September 2008 at RUSI (Royal United Services Institute), Whitehall, where the initial results were presented.

Publications:

Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, Hibbert CL, Truesdale A, Clemens F, Cooper N, Firmin RK, Elbourne D; CESAR trial collaboration. Lancet. 2009 Oct 17;374(9698):1351-63. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. . Epub 2009 Sep 15. Erratum in: Lancet. 2009 Oct 17;374(9698):1330.
(http://www.ncbi.nlm.nih.gov/pubmed/19762075)

Peek GJ, Elbourne D, Mugford M, Ventilatory support versus ECMO for severe adult respiratory failure - Authors' reply. Lancet, Volume 375, Issue 9714, Page 551, 13 February 2010
(http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60224-3/fulltext)

Thalanany MM, Mugford M, Hibbert C, Cooper NJ, Truesdale A, Robinson S, Tiruvoipati R, Elbourne DR, Peek GJ, Clemens F, Hardy P, Wilson A; CESAR Trial Group. Methods of data collection and analysis for the economic evaluation alongside a national, multi-centre trial in the UK: conventional ventilation or ECMO for Severe Adult Respiratory Failure (CESAR). BMC Health Serv Res. 2008 Apr 30;8:94
(http://www.biomedcentral.com/1472-6963/8/94)

Peek GJ, Clemens F, Elbourne D, Firmin R, Hardy P, Hibbert C, Killer H, Mugford M, Thalanany M, Tiruvoipati R, Truesdale A, Wilson A. CESAR: conventional ventilatory support vs extracorporeal membrane oxygenation for severe adult respiratory failure. BMC Health Serv Res. 2006 Dec 23;6:163
(http://www.biomedcentral.com/1472-6963/6/163)

Thalanany, MM; Mugford, M; Mitchell-Inwang, C. Visiting adult patients in intensive care; the importance of relatives travel and time costs. Intensive Crit Care Nurs. 2006 Feb;22(1):40-8. Epub 2005 Dec 1

Congratulations to all 70 centres who recruited at least one patient during July 2001 to August 2006

Best recruiting centres were: Bedford, Luton & Dunstable,Castle Hill, Glenfield, Gloucestershire, Royal Hallamshire, Leicester Royal, Queen Elizabeth Gateshead and Ayr Hospital

View full list of centres who have recruited

ECMO will continue to be provided by the team at Glenfield for NHS patients who would have been eligible for CESAR. Please call 0300 303 1573 and ask for the ECMO Coordinator. If you have a non-urgent question please email: giles.peek@uhl-tr.nhs.uk

For further information about ECMO useful links

CESAR site contents
News	Protocol and Summary Protocol	Recruiting centres
Recruitment LREC Approval Statement on SARS Statement on Bird Flu FAQs	Frequently Asked Questions	Economic Evaluation
	Information for patients and relatives	Newsletters and press releases
	CESAR Powerpoint presentations	ECMO events and training
	CESAR Induction packs	Useful links
	Emergency Inclusion Protocol (EIP)

If you require more information about CESAR please contact: Koro Diallo, CESAR Trial Administrator CESAR Data Co-ordinating Centre Medical Statistics Unit London School of Hygiene and Tropical Medicine Keppel Street, London WC1E 7HT Email Korotimi.Diallo@lshtm.ac.uk Telephone 020 7927 2376 Fax 020 7637 2853



ISRCTN47279827

The CESAR trial is comparing conventional ventilation methods with Extra-Corporeal Membrane Oxygenation for the treatment of severe acute respiratory failure in adults.