The CESAR trial is comparing conventional ventilation methods with Extra-Corporeal Membrane Oxygenation for the treatment of severe acute respiratory failure in adults.


Well done to all the CESAR collaborators - 180 patients recruited and 6 months follow up completed.

The first international presentation of the results in the public domain were by Giles Peek at the Society of Critical Care Medicine's 37th Critical Care Congess in Hawaii, February 2008.

The Final Collaborators meeting was held on Wednesday 5th September 2008 at RUSI (Royal United Services Institute), Whitehall, where the initial results were presented.


Congratulations to all 70 centres who recruited at least one patient during July 2001 to August 2006

Best recruiting centres were: Bedford, Luton & Dunstable,Castle Hill, Glenfield, Gloucestershire, Royal Hallamshire, Leicester Royal, Queen Elizabeth Gateshead and Ayr Hospital

View full list of centres who have recruited

ECMO will continue to be provided by the team at Glenfield for NHS patients who would have been eligible for CESAR. Please call 0300 303 1573 and ask for the ECMO Coordinator. If you have a non-urgent question please email:

For further information about ECMO useful links

  Patient Inclusion Criteria  
Patient Exclusion Criteria
Adult patients (18-65 years)
Duration of high pressure and/or high FiO2 ventilation >7 days
Severe, but potentially reversible, respiratory failure
Intra-cranial bleeding
Murray score > 3.0, or uncompensated hypercapnoea with a pH <7.20
Any other contra-indication to limited heparinisation
Patients who are moribund and have any
contra-indication to continuation of active treatment
Calculate the Murray Score for your patients!

  CESAR site contents

News Protocol and Summary Protocol Recruiting centres


LREC Approval

Statement on SARS

Statement on Bird Flu


Frequently Asked Questions  pdf icon Economic Evaluation
Information for patients and relatives Newsletters and press releases
CESAR Powerpoint presentations ECMO events and training
CESAR Induction packs Useful links
Emergency Inclusion Protocol (EIP)  

If you require more information about CESAR
please contact:

Koro Diallo, CESAR Trial Administrator
CESAR Data Co-ordinating Centre
Medical Statistics Unit
London School of Hygiene and Tropical Medicine
Keppel Street, London WC1E 7HT
Telephone 020 7927 2376
Fax 020 7637 2853





Health Technology Assessment
A national R&D programme for the NHS

CESAR is funded by the HTA
These pages were last updated November 25, 2009
Please contact if you have any comments about these pages
LSHTM London
School of
Hygiene &
Tropical Medicine